Senior Scientist - Genome Editing, Genomic Sciences and Target Discovery

Job Description: 

We are seeking an enthusiastic and highly motivated Senior Scientist to join the Genomic Sciences and Target Discovery team within Alkermes R&D, focusing on the application of genome-editing technologies to validate therapeutic hypotheses in vitro and in vivo for central nervous system (CNS) disorders. 

Key Responsibilities:  

• Design, develop, and execute CRISPR-based functional genomics strategies to validate therapeutic hypotheses in vitro and in preclinical models of CNS diseases. 
• Utilize CRISPR/Cas9, CRISPRa, and CRISPRi approaches to modulate gene expression and investigate target biology in the context of neuroanatomy and neurocircuitry. 
• Develop and optimize CRISPR delivery methodologies, including viral and non-viral delivery systems, for precise gene editing in the CNS. 
• Establish and validate CRISPR-edited rodent models using molecular, cellular, and behavioral readouts to assess target engagement and functional outcomes. 
• Collaborate cross-functionally with neuroscience, pharmacology, and translational teams to integrate functional genomics insights into drug discovery programs. 
• Perform molecular and cellular assays, including PCR, NGS, immunohistochemistry, and single-cell sequencing, to confirm CRISPR-mediated gene modifications. 
• Maintain detailed records of experimental design, execution, and data interpretation in accordance with corporate documentation standards. 
• Keep abreast of emerging CRISPR technologies and functional genomics advancements to drive innovation within the team. 
• Effectively communicate findings and recommendations to internal and external stakeholders. 

Required Qualifications:  

• Ph.D. in Neuroscience, Molecular Biology, Genomics, or a related field with a minimum of 3 years of relevant experience in functional genomics, preferably within industry-based CNS drug discovery and development. 
• Proficiency in human (Mendelian/population genetics) and model organism genetics 
• Expertise in CRISPR-based gene editing techniques, including CRISPR/Cas9, CRISPRa, and CRISPRi. 
• Experience with in vivo CRISPR delivery methods such as AAV, lipid nanoparticles, or electroporation for targeting CNS circuits. 
• Strong background in neuroanatomy and neurocircuitry, with experience in functional validation of gene edits in preclinical models. 
• Proficiency in standard molecular biology and tissue culture techniques, including developing and maintaining CRISPR-edited cell lines. 

• Familiarity with in vivo rodent models, behavioral assays, and CNS-relevant phenotypic assessments. 

• Strong data analysis and interpretation skills, with experience using bioinformatics tools for genomic analysis. 
• Excellent communication and collaboration skills in a cross-disciplinary research environment. 

Preferred Qualifications:  

• Experience with single-cell RNA sequencing, spatial transcriptomics, or electrophysiological techniques to assess gene function in CNS models.  

• Proficiency with computational tools (Python, R, or Unix CLI) for analyzing CRISPR screening data. 

The annual base salary for this position ranges from $151,000 to $170,000. In addition, this position is eligible for an annual performance pay bonus.  Exact compensation may vary based on skills, training, knowledge, and experience. Alkermes offers a competitive benefits package.  Additional details can be found on our careers website: www.alkermes.com/careers#working-here  

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